Trying to conceive for more than 2 years.

I am trying to conceive for more than 2 years. My prolactin levels are high It is 122.6ng/m. I have done a brain MRI everything is normal and currently taking tablet Cabgolin 0.25mg twice a weak. I also have LUFS syndrome. Have tried 4 follicle cycles but no rupture took place even with HCG injections have ovulation disorder. I have been asked to go for DNC hystero lap asap. I just wanted to know if my prolactin levels come down will I ovulate and conceive naturally or I have to go for Lap and If I have to go then when is it to be done.


Trying to conceive for more than 2 years.
Obstetrics & Gynae

Answer ( 1 )

  1. Hello Dear,

    Thank you for writing to us at MediMetry.
    In normal healthy fertile women, ovulation with rupture of the mature ovarian follicle and release of the eggs occurs within 38 hours of the surge in luteinizing hormone (LH). However, in a small percentage of women, the dominant follicle will undergo the luteinization process but will not rupture following the midcycle LH surge.

    This is called LUF (luteinized unruptured follicle syndrome). As a result of the increased progesterone secretion, the endometrium undergoes the secretory changes, but, obviously, without the release of the oocyte , pregnancy cannot occur. This means that the cycles are regular; and hormonal studies (Day 21 progesterone level) , the basal body temperature curve, and the findings in an endometrial biopsy will all be consistent with ovulation.

    This is obviously a difficult diagnosis to make; and can only be made by serial vaginal ultrasound scans to track ovulation. These scans show that the follicle matures; but the dominant follicle fails to rupture. The lack of follicle rupture and the lack of free peritoneal fluid around the time of ovulation are used to establish the diagnosis of LUF. This condition is also called "trapped egg syndrome".

    LUF is more commonly seen in women with endometriosis; and PCOD. Often the diagnosis is made only when patients are being monitored for follicle tracking with serial ultrasound scans and by diagnostic lap .LUF is a "silent" problem; and because it does not cause any symptoms or signs, it's very easy to miss the diagnosis as well !

    Since LH is responsible for inducing follicular rupture, LUF can be treated by giving an injection of Human Chorionic Gonadotropin (hCG) in a dose of 10,000 IU intramuscularly, when the lead follicle reaches 18-20 mm in diameter. Ultrasound can be used to document ovulation. It takes about 36 to 40 hours for the oocyte to be released after the injection. Intercourse or insemination should be timed accordingly. If it still does not take place, the dose of the hCG injection can be increased. If ovulation still cannot be achieved even with an increased dose of 20000 IU, then IVF is the best solution.
    Hope this answers your query. Feel free to write back to us with follow-up questions.
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